Going in circles: conserved mechanisms control radial patterning in the urinary and digestive tracts.

نویسنده

  • Cathy Mendelsohn
چکیده

Radial patterning in the urinary tract and gut depends on reciprocal signaling between epithelial cells, which form mucosa, and mesenchyme, which forms smooth muscle and connective tissue. These interactions depend on sonic hedgehog (Shh), which is secreted by epithelial cells and induces expression of bone morphogenetic protein 4 (Bmp4), a signaling molecule required for differentiation of smooth muscle progenitors. Patterning of the specialized mucosa lining the anterior-posterior (A-P) axis may be controlled independently by regionally expressed mesenchymal transcription factors. A study by Airik et al. in this issue of the JCI reveals that T-box 18 (Tbx18), a transcription factor selectively expressed in ureteral mesenchyme, regulates smooth muscle differentiation by maintaining Shh1 responsiveness in mesenchymal progenitors (see the related article beginning on page 663). Deletion of Tbx18 resulted in defective urothelial differentiation at the level of the ureter, suggesting that Tbx18 acts via mesenchyme as an important regulator of A-P patterning in the urinary tract.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Characteristics of some digestive enzymes in sobaity, Sparidentex hasta

Background: Determination of digestive enzymes activity would provide critical information in the design of appropriate diet. Sobaity, Sparidentex hasta is found in the Persian Gulf and  cultured in countries adjacent to it. OBJECTIVES: This study investigated proteolytic, amylase and lipase activities in the intestine of Sparidentex hasta captured from the  Persian Gulf. METHODS: 60 immature S...

متن کامل

Therapeutic effects of saffron (Crocus sativus L.) in digestive disorders: a review

Saffron, the dried red-orange stigmas of Crocus sativus L, has been known as a flavoring agent, food coloring and traditional herbal medicine. Pharmacological effects of saffron are mainly attributed to crocin, crocetin, picrocrocin and safranal. These components especially crocin, have significant effects including antidepressant and anticonvulsant, analgesic, anti-cancer and other therapeutic...

متن کامل

Numerical Simulation of 1D Linear Telegraph Equation With Variable Coefficients Using Meshless Local Radial Point Interpolation (‎MLRPI)

In the current work, we implement the meshless local radial point interpolation (MLRPI) method to find numerical solution of one-dimensional linear telegraph equations with variable coefficients. The MLRPI method, as a meshless technique, does not require any background integration cells and all integrations are carried out locally over small quadrature domains of regular shapes, such as lines ...

متن کامل

Bioinformatics analysis and expression of a truncated form of Proteus mirabilis Pta protein as a novel vaccine target against urinary tract infection

Introduction: Pathogenic strains of Proteus mirabilis have important roles in urinary tract infection. Proteus toxic agglutinin (Pta) is amongst the most important virulence factors of P. mirabilis. This protein has a conserved sequence present in all the strains which could be evaluated as a novel vaccine target against them. The aims of the current study were the expression, purification and ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Journal of clinical investigation

دوره 116 3  شماره 

صفحات  -

تاریخ انتشار 2006